The model, which simulates every NFL game 10,000 times, is up more than $5,000 for $100 players on betting sites on top-rated NFL picks since its inception. The model entered Week 6 of the 2026 NFL season on a 57-46 run on top-rated picks dating back to 2024. Anybody following its picks at NFL betting sites could have seen strong returns.

The Seahawks need to clean up their offense with a limited running game and Sam Darnold struggling to protect the ball. They get a short-week break on the road with the Broncos ' cornerbacks hurting, setting up Jaxon Smith-Njigba to explode again. Their defense also will make it rough on an inefficient Bo Nix.

We're already through Week 5 of the NFL season, and it's time to lock in our bets for Week 6. Four teams are on BYE, which leaves us with 14 games to watch and

The unbeatable Los Angeles Rams superteam is now 2-3 on the 2026 NFL season. The Houston Texans just got their first win. The Dallas Cowboys can't get out of th

SportsLine's model enters Week 6 of the 2026 NFL season on a 57-46 run on top-rated picks dating back to 2024. One of its favorite picks at the best betting apps is the Cardinals (+12.5, 51.5) covering versus the Rams, which cashes 56% of the time. You can find the model's picks for every NFL Week 6 game here.

We like Walker and the Chiefs to keep rolling over the Chargers, but maybe pump the brakes on the Patriots and Bills.

NFL picks for every Week 6 game with predictions straight-up and against the spread. The Broncos have a huge problem on their hands if Bo Nix is THIS afraid to throw deep. More in our weekly NFL Power Rankings.

Projected score: Panthers 23, Eagles 21 The pick: Panthers +1.5